Indications of Mecolagin 0.5 mg

Mecolagin 0.5 mg is indicated in- Peripheral Neuropathies Diabetic Neuropathy Verteberal Syndrome Nerve Compression Syndrome Multiple sclerosis Amyotrophic lateral sclerosis Parkinson’s disease Alzheimer’s disease ... Read moreMecolagin 0.5 mg is indicated in- Peripheral Neuropathies Diabetic Neuropathy Verteberal Syndrome Nerve Compression Syndrome Multiple sclerosis Amyotrophic lateral sclerosis Parkinson’s disease Alzheimer’s disease Diabetic retinopathy Entrapment neuropathy Drug induced neuropathy Megaloblastic anemia due to Vitamin B12 deficiency

Theropeutic Class

Drugs for Megaloblastic Anemia

Pharmacology

Mecolagin 0.5 mg is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Dosage & Administration of Mecolagin 0.5 mg

Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms. Injection: Peripheral neuropathies: The usual adult dosage is  500 mcg Mecolagin 0.5 mg administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.  Megaloblastic anemia: The usual adult dosage is  500 mcg Mecolagin 0.5 mg administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecolagin 0.5 mg every one to three months as maintenance therapy

Dosage of Mecolagin 0.5 mg

Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms. Injection: Peripheral neuropathies: The usual adult dosage is  500 mcg Mecolagin 0.5 mg administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.  Megaloblastic anemia: The usual adult dosage is  500 mcg Mecolagin 0.5 mg administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecolagin 0.5 mg every one to three months as maintenance therapy

Interaction of Mecolagin 0.5 mg

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Contraindications

Hypersensitivity to any component of this product.

Side Effects of Mecolagin 0.5 mg

Generally Mecolagin 0.5 mg is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecolagin 0.5 mg.

Pregnancy & Lactation

Not recommended during pregnancy & lactation.

Precautions & Warnings

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Storage Conditions

Oral: Store at room temperature. Protect from moisture and light.Parenteral: Store at room temperature. Do not expose to direct light.

Use In Special Populations

Use in children: Not recommended.

Drug Classes

Drugs for Megaloblastic Anemia

Mode Of Action

Mecolagin 0.5 mg is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Pregnancy

Not recommended during pregnancy & lactation.

Pediatric Uses

Use in children: Not recommended.

Medicine are subject to availability and supply from the production company. The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice with a doctor. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.